A rejoint le : 13 mai 2022

À propos

Cadimagetoolsforarchicad1214 adogeeg


Download: role of the liver in the toxicology of paracetamol. This review has been written to examine the role of the liver in the toxicity of paracetamol. The possibility of an idiosyncratic sensitivity to this drug has been evaluated and that specific therapeutic measures can reduce the hepatic and systemic toxicity of paracetamol has been tested in animal models. All three stages of paracetamol metabolism have been examined with regard to their involvement in the mechanism of hepatotoxicity. The mechanism of drug-induced cholestasis is considered in detail. The toxicity of paracetamol is thought to be largely due to the oxidative metabolism of this drug to N-acetyl-p-benzoquinone imine (NAPQI). The formation of NAPQI in the liver is not essential for the toxicity of paracetamol. Chloroform, the main metabolite of paracetamol, does not cause any toxicity in itself and is incapable of directly inducing DNA strand breaks. Oxidative stress does not play any important role in the toxicity of paracetamol. In general, the toxic effects of paracetamol can be ascribed to its sulphydryl-reactive metabolites. A reduction in the extent of oxidative stress may help to reduce the toxicity of paracetamol and this may occur either by increasing the capacity of the liver to detoxify reactive metabolites or by inhibiting the formation of reactive metabolites by the cytochrome P450 system. The toxicity of paracetamol can be reduced by the use of NAC or anti-oxidants.Determination of circulating soluble IL-2 receptors in patients with malignant and benign diseases. We measured the levels of soluble interleukin-2 receptor (sIL-2r) in the sera of 15 patients with malignant diseases (eight with hematological malignancies and seven with solid tumors), eight patients with benign diseases (eight with viral hepatitis and one




MyLanViewer v4.18.6 Incl Patch

alen kar lako je smrsati

Planescape.Torment.iso [4CD] [PL] [Arx] free

willey studios mirna model set (20.24 mb).rar

namirial termo 2.2

Cadimagetoolsforarchicad1214 adogeeg

Plus d'actions